7832. Propiverine

Nomenclature

CAS number: 60569-19-9
α-Phenyl-α-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester; α,α-diphenyl-α-propoxyacetic acid 1-methyl-4-piperidyl ester; 1-methyl-4-piperidyl diphenylpropoxyacetate.
C23H29NO3; mol wt 367.48.
C 75.17%, H 7.95%, N 3.81%, O 13.06%.

Description and references

Prepn: C. Starke et al., DD 106643 (1974), C.A. 82, 155841s (1975). GC-MS determn in plasma and urine: T. Marunaka et al., J. Chromatogr. 420, 43 (1987). Pharmacology: A. Haruno, Arzneim.-Forsch. 42, 815, 1459 (1992). Acute toxicity: K. Yamashita et al., J. Toxicol. Sci. 14, Suppl. 2, 1 (1989), C.A. 112, 172060 (1990). Clinical pharmacokinetics: C. Müller et al., Eur. J. Drug Metab. Pharmacokinet. 18, 265 (1993). Clinical trial in urinary incontinence: D. Mazur et al., Urologe A33, 447 (1994).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 54556-98-8
P-4; Detrunorm (Schering); Mictonorm (Apogepha); Mictonetten (Apogepha).
C23H29NO3.HCl; mol wt 403.94.
C 68.39%, H 7.49%, N 3.47%, O 11.88%, Cl 8.78%.

Properties

mp 216-218°. Sparingly sol in water and ethanol. LD50 in male, female mice, male, female rats (mg/kg): 36, 36, 22, 25 i.v.; 223, 283, 1632, 1411 s.c.; 410, 323, 1000, 1092 orally (Yamashita).

Therapeutic Category

In treatment of urinary incontinence.

Keywords

Antimuscarinic