7891. Protionamide

Nomenclature

CAS number: 14222-60-7
2-Propyl-4-pyridinecarbothioamide; 2-propylthioisonicotinamide; prothionamide; 2-propyl-4-thiocarbamoylpyridine; Ektebin (Hefa); Peteha (Fatol); Trevintix (Théraplix).
C9H12N2S; mol wt 180.27.
C 59.96%, H 6.71%, N 15.54%, S 17.79%.

Description and references

Prepn: D. Liberman et al., Compt. Rend. 242, 2409 (1956); GB 800250, D. Liberman, US 2901488 (1958, 1959 both to Chimie et Atomistique); L. N. Yakhontov et al., Khim. Farm. Zh. 10, 96 (1976), C.A. 85, 32787h (1976). Pharmacology: A. M. Il'in, Farmakol. Toksikol. 38, 471 (1975).

Chemical structure

Properties

Crystals, mp 142°. Sol in ethanol, methanol; slightly sol in ether, chloroform. Practically insol in water. LD50 in mice, rats (g/kg): 1.0, 1.32 orally (Il'in).

Therapeutic Category

Antibacterial (tuberculostatic).

Keywords

Antibacterial (Tuberculostatic)