7903. Proxazole

Nomenclature

CAS number: 5696-09-3
N,N-Diethyl-3-(1-phenylpropyl)-1,2,4-oxadiazole-5-ethanamine; 5-[2-(diethylamino)ethyl]-3-(α-ethylbenzyl)-1,2,4-oxadiazole; propaxoline.
C17H25N3O; mol wt 287.40.
C 71.04%, H 8.77%, N 14.62%, O 5.57%.

Description and references

Smooth muscle relaxant. Prepn: GB 924608; Palazzo, Silvestrini, US 3141019 (1963, 1964 both to Angelini Francesco). Pharmacology: Silvestrini, Pozzatti, Arzneim.-Forsch. 13, 798 (1963). Separation and pharmacology of the enantiomers: De Feo et al., Farmaco Ed. Sci. 26, 370 (1971). Clinical trial in cerebrovascular insufficiency: G. Esposito, M. De Gregorio, Arzneim.-Forsch. 24, 1692 (1974).

Chemical structure

Properties

bp0.2 132°.

Derivative

Citrate.

Nomenclature

CAS number: 132-35-4
AF-634; Flou (ELEA); Pirecin (Yoshitomi); Toness (Angelini).
C17H25N3O.C6H8O7; mol wt 479.52.
C 57.61%, H 6.94%, N 8.76%, O 26.69%.

Properties

LD50 in rats (mg/kg): 39 i.p., 60 orally (Silvestrini, Pozzatti).

Derivative

Nitrate.

Properties

Crystals, mp 127-128°.

Therapeutic Category

Antispasmodic.

Therapeutic Category (Veterinary)

Antispasmodic.

Keywords

Antispasmodic