7905. Proxyphylline

Nomenclature

CAS number: 603-00-9
3,7-Dihydro-7-(2-hydroxypropyl)-1,3-dimethyl-1H-purine-2,6-dione; 7-(2-hydroxypropyl)theophylline; Brontyl (Reckitt Benckiser); Spasmolysin (Kade); Theon (Bock).
C10H14N4O3; mol wt 238.24.
C 50.41%, H 5.92%, N 23.52%, O 20.15%.

Description and references

Smooth muscle relaxant. Prepd by refluxing 1-chloro-2-propanol with theophylline in an alkaline medium: Rice, US 2715125 (1955 to Gane's Chem. Works).

Chemical structure

Properties

Crystals from abs ethanol, mp 135-136°. One gram dissolves in about 1 ml water, in 14 ml abs ethanol. More sol in boiling ethanol. pH of a 5% aq soln 5.5 to 7.0. Solns may be sterilized by heating.

Therapeutic Category

Bronchodilator; vasodilator.

Keywords

Bronchodilator; Xanthine Derivatives