7955. Pyrantel

Nomenclature

CAS number: 15686-83-6
(E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]pyrimidine.
C11H14N2S; mol wt 206.31.
C 64.04%, H 6.84%, N 13.58%, S 15.54%.

Description and references

Prepn: BE 658987 (1965 to Pfizer), C.A. 64, 8192c (1966); Austin et al., Nature 212, 1273 (1966); Kasubrick, McFarland, ZA 6800516; eidem, US 3502661 (1968, 1970 both to Pfizer). Structure-activity studies: McFarland et al., J. Med. Chem. 12, 1066 (1969). Pharmacology and animal trials: Cornwell, Vet. Rec. 79, 590 (1966); Howes, Lynch, J. Parasitol. 53, 1085 (1967); Eyre, J. Pharm. Pharmacol. 22, 26 (1970).

Chemical structure

Properties

Crystals from methanol, mp 178-179°.

Derivative

Tartrate.

Nomenclature

CAS number: 33401-94-4
CP-10423-18; Banminth (Pfizer); Strongid (Pfizer).
C11H14N2S.C4H6O6; mol wt 356.39.
C 50.55%, H 5.66%, N 7.86%, S 9.00%, O 26.94%.

Properties

White crystals from hot methanol, mp 148-150°. uv max (water): 312 nm (log ε 4.27).

Derivative

Pamoate.

Nomenclature

CAS number: 22204-24-6
Pyrantel embonate; CP-10423-16; Cobantril (Pfizer); Combantrin (Pfizer); Helmex (Infectopharm); Helmintox (Innothéra); Nemex (Pfizer).
C11H14N2S.C23H16O6; mol wt 594.68.
C 68.67%, H 5.08%, N 4.71%, S 5.39%, O 16.14%.

Properties

Tasteless, yellow crystalline powder. Insol in water.

Therapeutic Category

Anthelmintic (Nematodes).

Therapeutic Category (Veterinary)

Anthelmintic (Nematodes).

Keywords

Anthelmintic (Nematodes)