7975. Pyridinol Carbamate

Nomenclature

CAS number: 1882-26-4
2,6-Pyridinedimethanol bis(methylcarbamate) (ester); 2,6-pyridinylenebis[methyl-N-methylcarbamate]; pyricarbate; H-3749; Anginin (Banyu); Angioxine (Roussel Diamant); Aterosan (Aanderson); Atover (Recordati); Cicloven (AGIPS); Colesterinex (Galenica); Duvaline (Almirall); Movecil (Farmitalia); Prodectin (Gedeon Richter); Ravenil (Caber); Sospitan (Kali-Chemie); Vasagin (Salus); Vasocil (Magis); Vasoverin (Banyu).
C11H15N3O4; mol wt 253.25.
C 52.17%, H 5.97%, N 16.59%, O 25.27%.

Description and references

Prepd by the reaction of methylamine with 2,6-pyridinedimethanol bis[phenylcarbonate] in methanol: Matsumoto, JP 66 22185 (1966 to Banyu), C.A. 66, 75907x (1967). Pharmacology and clinical evaluation: T. Shimamoto et al., Am. Heart J. 71, 297 (1966). Metabolism: Mallein et al., Therapie 28, 115 (1973). Effects on lipid metabolism and antiatherogenic effect in animals: V. Orbetzova et al., Artery 8, 560 (1980). HPLC determn in biological fluids: A. Suenaga et al., Acta Pharm. Suec. 23, 245 (1986).

Chemical structure

Properties

Needles from methanol or acetone, mp 136-137°. uv max (methanol): 264-265 nm. Sparingly sol in cold water; freely sol in hot water. LD50 in mice, rats, rabbits, dogs (mg/kg): 4500, 3400, 5200, 1000 orally (Shimamoto).

Therapeutic Category

Antiarteriosclerotic.

Keywords

Antiatherosclerotic