8002. Pyrolan

Nomenclature

CAS number: 87-47-8
Dimethylcarbamic acid 3-methyl-1-phenyl-1H-pyrazol-5-yl ester; 1-phenyl-3-methyl-5-pyrazolyl dimethylcarbamate; 3-methyl-1-phenyl-5-pyrazolyl dimethylcarbamate; ENT-17588; G-22008.
C13H15N3O2; mol wt 245.28.
C 63.66%, H 6.16%, N 17.13%, O 13.05%.

Description and references

Prepn from 1-phenyl-3-methyl-5-pyrazolone and dimethylcarbamoyl chloride: CH 279553 (1952 to Geigy); GB 681376. Anticholinesterase activity: Pulver, Domenjoz, Experientia 7, 306 (1951); Ferguson, Alexander, J. Agric. Food Chem. 1, 888 (1953); Müller, Spindler, Experientia 10, 91 (1954). Toxicity study: E. W. Schafer, Toxicol. Appl. Pharmacol. 21, 315 (1972).

Chemical structure

Properties

Crystals, mp 50°. bp0.2 160-162°. Possesses water and lipid solubility. LD50 orally in rats: 62 mg/kg (Schafer).

Caution

Cholinesterase inhibitor.

Use

Insecticide.