8010. Pyrovalerone
Nomenclature
CAS number: 3563-49-3
1-(4-Methylphenyl)-2-(1-pyrrolidinyl)-1-pentanone; 4′-methyl-2-(1-pyrrolidinyl)valerophenone; α-pyrrolidino-p-methylvalerophenone; 1-(1-pyrrolidinyl)butyl p-tolyl ketone; 1-(p-tolyl)-1-oxo-2-pyrrolidino-n-pentane; 1-(p-tolyl)-2-pyrrolidino-1-pentanone. C16H23NO; mol wt 245.36.
C 78.32%, H 9.45%, N 5.71%, O 6.52%.
Description and references
Prepn: GB 927475 (1963 to Wander); GB 933507; E. Seeger, US 3314970 (1963, 1967 both to Thomae); Heffe, Helv. Chim. Acta 47, 1289 (1964). Pharmacology: Stille et al., Arzneim.-Forsch. 13, 871 (1963). Metabolism: Michaelis et al., J. Med. Chem. 13, 497 (1970).
Properties
bp0.08 104°.Derivative
Hydrochloride.Nomenclature
CAS number: 1147-62-2
F-1983; Centroton (Wander); Thymergix (Joulli). C16H23NO.HCl; mol wt 281.82.
C 68.19%, H 8.58%, N 4.97%, O 5.68%, Cl 12.58%.
Properties
Crystals from 2-butanone or from methanol + acetone + diethyl ether, mp 178°. LD50 orally in mice: 350 mg/kg (Stille).Note
This is a controlled substance (stimulant): 21 CFR, 1308.15.Therapeutic Category
CNS stimulant.
Keywords
CNS Stimulant