8039. Quetiapine

Nomenclature

CAS number: 111974-69-7
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol; 11-[4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine.
C21H25N3O2S; mol wt 383.51.
C 65.77%, H 6.57%, N 10.96%, O 8.34%, S 8.36%.

Description and references

Combined serotonin (5HT2) and dopamine (D2) receptor antagonist. Prepn: E. J. Warawa, B. M. Migler, EP 240228; eidem, US 4879288 (1987, 1989 both to ICI). HPLC and GC/MS determn in plasma: R. H. Pullen et al., J. Chromatogr. 573, 49 (1992). Series of articles on pharmacology: Psychopharmacology 112, 285-307 (1993). Clinical evaluation in schizophrenia: H. Wetzel et al., ibid. 119, 231 (1995). Review of clinical experience: B. Green, Curr. Med. Res. Opin. 15, 145-151 (1999).

Chemical structure

Derivative

Hemifumarate.

Nomenclature

CAS number: 111974-72-2
ICI-204636; Seroquel (AstraZeneca).
(C21H25N3O2S)2.C4H4O4; mol wt 883.09.
C 62.56%, H 6.16%, N 9.52%, O 14.49%, S 7.26%.

Properties

Crystals from ethanol, mp 172-173°.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Other Tricyclics; Serotonin-Dopamine Antagonist