8106. Ranelic Acid

Nomenclature

CAS number: 135459-90-4
5-[Bis(carboxymethyl)amino]-2-carboxy-4-cyano-3-thiopheneacetic acid; 2-[N,N-di(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid.
C12H10N2O8S; mol wt 342.28.
C 42.11%, H 2.94%, N 8.18%, O 37.39%, S 9.37%.

Description and references

Prepn: M. Wierzbicki et al., EP 415850; eidem, US 5128367 (1991, 1992 both to Adir & Co.).

Chemical structure

Properties

Crystals from ethyl ether, contains 4% ether.

Derivative

Strontium salt.

Nomenclature

CAS number: 135459-87-9
Strontium ranelate; S-12911; Osseor (Servier); Protelos (Servier); Protos (Servier).
C12H6N2O8SSr2; mol wt 513.49.
C 28.07%, H 1.18%, N 5.46%, O 24.93%, S 6.24%, Sr 34.13%.

Description and references

Bone metabolism modulator; inhibits bone resorption while maintaining bone formation. Effect on human chondrocytes in vitro: Y. Henrotin et al., J. Bone Miner. Res. 16, 299 (2001). Effect on bone remodeling in monkeys: J. Buehler et al., Bone 29, 176 (2001). Clinical trial in postmenopausal osteoporosis: P. J. Meunier et al., N. Engl. J. Med. 350, 459 (2004).

Therapeutic Category

Strontium salt as antiosteoporotic.

Keywords

Strontium Ranelate: Antiosteoporotic; Bone Resorption Inhibitor