8143. Reserpic Acid

Nomenclature

CAS number: 83-60-3
(3β,16β,17α,18β,20α)-18-Hydroxy-11,17-dimethoxyyohimban-16-carboxylic acid; reserpinolic acid.
C22H28N2O5; mol wt 400.47.
C 65.98%, H 7.05%, N 7.00%, O 19.98%.

Description and references

Obtained by controlled alkaline hydrolysis of reserpine: Dorfman et al., Helv. Chim. Acta 37, 59 (1954); Schlittler, US 2824874 (1958).

Chemical structure

Properties

Crystals from methanol, mp 241-243°.

Derivative

Hydrochloride hemihydrate.
C22H28N2O5.HCl. 1/2 H2O; mol wt 445.94.
C 59.25%, H 6.78%, N 6.28%, O 19.73%, Cl 7.95%.

Properties

Crystals, mp 257-259°. [α]D23 -81°.

Derivative

Methyl ester.
C23H30N2O5; mol wt 414.49.
C 66.65%, H 7.30%, N 6.76%, O 19.30%.

Properties

Needles from methanol, mp 235-240°. [α]D25 -106°.

Derivative

Methyl ester hydrochloride.

Properties

mp ≈228°.