8227. Rimiterol

Nomenclature

CAS number: 32953-89-2
4-(Hydroxy-2-piperidinylmethyl)-1,2-benzenediol; erythro-α-(3,4-dihydroxyphenyl)-2-piperidinemethanol; erythro-3,4-dihydroxyphenyl-2-piperidinylcarbinol.
C12H17NO3; mol wt 223.27.
C 64.55%, H 7.67%, N 6.27%, O 21.50%.

Description and references

Prepn: G. H. Sankey, K. D. E. Whiting, DE 2024049; idem, US 3910934 (1970, 1975 to 3M); C. Kaiser, S. T. Ross, DE 2047937; idem, US 3705169 (1971, 1972 to SK & F); G. H. Sankey, K. D. E. Whiting, J. Heterocycl. Chem. 9, 1049 (1972). Pharmacology: Carney et al., Arch. Int. Pharmacodyn. Ther. 194, 334 (1971); Griffin, Turner, J. Clin. Pharmacol. 11, 280 (1971); Bowman, Rodger, Br. J. Pharmacol. 45, 574 (1972).

Chemical structure

Properties

Crystals from ethyl acetate, mp 203-204°.

Derivative

Hydrobromide.

Nomenclature

CAS number: 31842-61-2
R-798; WG-253; Asmaten (3M Pharma); Pulmadil (3M Pharma).
C12H17NO3.HBr; mol wt 304.18.
C 47.38%, H 5.96%, N 4.60%, O 15.78%, Br 26.27%.

Properties

White powder, mp 220° (dec).

Therapeutic Category

Bronchodilator.

Keywords

β-Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives