Description and references

Glycopeptide antibiotic complex produced by the actinomycete Nocardia lurida. Ristocetin A and the more active ristocetin B differ in the number of glucose, mannose, rhamnose and d-arabinose groups in their side chains. Isoln, crystallizn and chemical properties: J. E. Philip et al., Antibiot. Annu. 1956-57, p 699; eidem, US 2990329 (1961 to Abbott). Total structure determn of ristocetin A: D. H. Williams et al., Chem. Commun. 1979, 906; J. R. Kalman, D. H. Williams, J. Am. Chem. Soc. 102, 897 (1980). Identity of ristocetin A with ristomycin A: D. H. Williams et al., J. Chem. Soc. Perkin Trans. 1 1979, 787. ¹³C-NMR studies: F. Sztaricskai et al., Tetrahedron Lett. 21, 2983 (1980); M. P. Williamson, D. H. Williams, J. Chem. Soc. Perkin Trans. 1 1981, 1483. Revised configuration: C. M. Harris, T. M. Harris, J. Am. Chem. Soc. 104, 363 (1982). Biosynthesis: S. J. Hammond et al., Chem. Commun. 1983, 116. Tool for investigation of platelet aggregation: Howard, Firkin, Thromb. Diath. Haemorrh. 26, 362 (1971). Review: D. C. Jordan, Antibiotics vol. 1, D. Gottlieb, P. Shaw, Eds. (Springer-Verlag, New York, 1967) pp 84-89.

Derivative

Derivative

Derivative