8246. Rocuronium

Nomenclature

CAS number: 143558-00-3
1-[(2β,3α,5α,16β,17β)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium; 1-allyl-1-(3α,17β-dihydroxy-2β-morpholino-5α-androstan-16β-yl)pyrrolidinium 17-acetate.
[C32H53N2O4]+.

Description and references

Aminosteroid, competitive neuromuscular blocker. Prepn: D. S. Savage et al., EP 287150; T. Sleigh et al., US 4894369 (1988, 1990 both to Akzo). Pharmacology: A. W. Muir et al., Br. J. Anaesth. 63, 400 (1989); K. Khuenl-Brady et al., Anesthesiology 72, 669 (1990). Clinical pharmacodynamics: T. J. Quill et al., Anesth. Analg. 72, 203 (1991); and pharmacokinetics in the elderly: R. S. Matteo et al., ibid. 77, 1193 (1993). Comparative clinical trial: T. Magorian et al., Anesthesiology 79, 913 (1993). HPLC determn: U. W. Kleef et al., J. Chromatogr. 621, 65 (1993). Review: T. C. Wicks, J. Am. Assoc. Nurse Anesth. 62, 33-38 (1994).

Chemical structure

Derivative

Bromide.

Nomenclature

CAS number: 119302-91-9
Org-9426; Esmeron (Organon); Zemuron (Akzo).
C32H53BrN2O4; mol wt 609.68.
C 63.04%, H 8.76%, Br 13.11%, N 4.59%, O 10.50%.

Properties

Crystals, mp 161-169°. [α]D20 +18.7° (c = 1.03 in CHCl3).

Therapeutic Category

Neuromuscular blocking agent.

Keywords

Neuromuscular Blocking Agent; Nondepolarizing Agents