8273. Roxarsone

Nomenclature

CAS number: 121-19-7
4-Hydroxy-3-nitrophenylarsonic acid; 4-hydroxy-3-nitrobenzenearsonic acid; 3-nitro-4-hydroxyphenylarsonic acid; 2-nitro-1-hydroxybenzene-4-arsonic acid; nitrophenolarsonic acid; NSC-2101; Ren-o-sal (Salsbury).
C6H6AsNO6; mol wt 263.04.
C 27.40%, H 2.30%, As 28.48%, N 5.32%, O 36.49%.

Description and references

Prepd by treating sodium p-hydroxyphenylarsonate with a mixture of nitric and sulfuric acids at 0°: Benda, Bertheim, Ber. 44, 3446 (1911); DE 224953 C.A. 5, 156 (1911). Toxicity study: Kerr et al., Toxicol. Appl. Pharmacol. 5, 507 (1963). Review of toxicology and human exposure: Toxicological Profile for Arsenic (PB2000-108021, 2000) 468 pp.

Chemical structure

Properties

Tufts of pale-yellow needles or rhombohedral plates from water. Puffs up and deflagrates on heating. Slightly sol in cold water; sol in ≈30 parts boiling water; freely sol in methanol, ethanol, acetic acid, acetone, alkalies; sparingly sol in dil mineral acids. Insol in ether, ethyl acetate. Forms mono-, di-, and trisodium salts. LD50 in rats, chickens (mg/kg): 155, 110-123 orally; 66, 34 i.p. (Kerr).

Use

Formerly in manuf arsphenamines; as reagent for zirconium.

Therapeutic Category (Veterinary)

Control of enteric infections. To improve growth and feed efficiency.