8275. Roxindole

Nomenclature

CAS number: 112192-04-8
3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol; 5-hydroxy-3-[4-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole.
C23H26N2O; mol wt 346.47.
C 79.73%, H 7.56%, N 8.09%, O 4.62%.

Description and references

Dopamine D2-receptor agonist. Synthesis: H.-H. Hausberg et al., Acta Pharm. Suec. 1983, Suppl 2, 213; H. B"ottcher et al., J. Med. Chem. 35, 4020 (1992). Pharmacology: C. A. Seyfried et al., Eur. J. Pharmacol. 160, 31 (1989). Clinical pharmacology: K. Wiedemann, M. Kellner, Exp. Clin. Endocrinol. 102, 284 (1994). Clinical evaluation in schizophrenia: H. Wetzel et al., Am. J. Psychiatry 151, 1499 (1994); in depression: G. Gründer et al., Psychopharmacology 111, 123 (1993). Neuroendocrinology in schizophrenics: G. Gründer et al., ibid. 117, 472 (1995).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 108050-82-4
EMD-38362.
C23H26N2O.HCl; mol wt 382.93.
C 72.14%, H 7.11%, N 7.32%, O 4.18%, Cl 9.26%.

Properties

Monoclinic crystals, mp 274°.

Derivative

Methanesulfonate.

Nomenclature

CAS number: 119742-13-1
Roxindole mesylate; EMD-49980.

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Dopamine Receptor Agonist