8424. Selamectin

Nomenclature

CAS number: 220119-17-5
(5Z)-25-Cyclohexyl-4′-O-de(2,6-dideoxy-3-O-methyl-α-l-arabino-hexopyranosyl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)avermectin A1a; 5-oxoimino-25-cyclohexyl avermectin B1 monosaccharide; Revolution (Pfizer).
C43H63NO11; mol wt 769.96.
C 67.08%, H 8.25%, N 1.82%, O 22.86%.

Description and references

Antiparasitic semisynthetic avermectin, q.v. Prepn: B. F. Bishop et al., WO 9415944; eidem, US 5981500 (1994, 1999 both to Pfizer).

Chemical structure

Properties

Waterfast, no unpleasant odor.

Therapeutic Category (Veterinary)

Anthelmintic; ectoparasiticide.