8462. Serotonin

Nomenclature

CAS number: 50-67-9
3-(2-Aminoethyl)-1H-indol-5-ol; 5-hydroxytryptamine; 3-(β-aminoethyl)-5-hydroxyindole; 5-hydroxy-3-(β-aminoethyl)indole; enteramine; thrombocytin; thrombotonin; 5-HT.
C10H12N2O; mol wt 176.22.
C 68.16%, H 6.86%, N 15.90%, O 9.08%.

Description and references

Vasoactive amine found in tissues and fluids of vertebrates and invertebrates. Extraction of enteramine from rabbit tissue, pharmacology: V. Erspamer, Arch. Exp. Pathol. Pharmakol. 196, 343 (1940). Isoln of 5-HT from beef serum: M. M. Rapport et al., Science 108, 329 (1948); eidem, J. Biol. Chem. 176, 1237, 1243 (1948); M. M. Rapport, ibid. 180, 961 (1949). Identity with enteramine, the enterochromaffin cell hormone: V. Erspamer, B. Asero, Nature 169, 800 (1952). Ultrastructural localization in enterochromaffin cells: R. D. Dey, J. Hoffpauir, J. Histochem. Cytochem. 32, 661 (1984). Synthesis starting with 5-benzyloxyindole: M. E. Speeter et al., J. Am. Chem. Soc. 73, 5514 (1951); K. E. Hamlin, US 2715129 (1955 to Abbott). Alternate routes: R. Justoni, R. Pessina, US 2947757 (1960 to Vismara). Pharmacology: G. Reid, M. Rand, Nature 169, 801 (1952). Existence of multiple serotonin receptors: S. J. Peroutka, S. H. Snyder, Mol. Pharmacol. 16, 687 (1979); G. Engel et al., Arch. Pharmacol. 324, 116 (1983); W. Feniuk et al., Eur. J. Pharmacol. 96, 71 (1983). Extraneural synthesis in CNS: C. Maruki et al., J. Neurochem. 43, 316 (1984). Effect on smooth muscle: W. Feniuk et al., loc. cit. Activity as neurotransmitter: S. G. Griffith et al., Brain Res. 247, 388 (1982). Role in hemostasis: F. De Clerck et al., Agents Actions 15, 627 (1984). Series of articles on role in hypertension, Raynaud's phenomenon and platelet activation: J. Cardiovasc. Pharmacol. 7, Suppl. 7, 1-182 (1985). Review of role in migraine: E. T. MacKenzie et al., Cephalalgia 5, 69-78 (1985). Review: V. Erspamer in E. Jucker, Prog. Drug Res. 3, 151-367 (1961). Books: Serotonin in Health and Disease vols. I-V, W. B. Essman, Ed. (Spectrum, New York, 1978); Adv. Exp. Med. 133, entitled “Serotonin: Current Aspects of Neurochemistry and Function,” B. Haber, Ed. (1981) 824 pp; Serotonin and the Cardiovascular System, P. M. Vanhoutte, Ed. (Raven Press, New York, 1985) 280 pp. See also Bufotenine and Ketanserin.

Chemical structure

Derivative

Hydrochloride.
C10H12N2O.HCl; mol wt 212.68.
C 56.47%, H 6.16%, N 13.17%, O 7.52%, Cl 16.67%.

Properties

Hygroscopic crystals, sensitive to light, mp 167-168°. Water sol. Aq solns are stable at pH 2-6.4.

Derivative

Complex with creatinine sulfate, monohydrate.

Nomenclature

Antemovis (Vister).
C14H21N5O6S.H2O; mol wt 405.43.
C 41.47%, H 5.72%, N 17.27%, O 27.62%, S 7.91%.

Properties

Plates, 215° dec. uv max (water at pH 3.5): 275 nm (ε 15000). pK1′ = 4.9; pK2′ = 9.8. pH of 0.01 molar aq soln: 3.6. Sol in glacial acetic acid. Very sparingly sol in methanol, 95% ethanol. Insol in abs ethanol, acetone, pyridine, chloroform, ethyl acetate, ether, benzene.