8472. Setastine

Nomenclature

CAS number: 64294-95-7
1-[2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]hexahydro-1H-azepine; 1-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]hexahydro-1H-azepine; 1-[2-(4-chloro-α-methyl-α-phenylbenzyloxy)ethyl]azepam; N-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]hexamethyleneimine; N-[2-[(4-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]hexamethylenimine.
C22H28ClNO; mol wt 357.92.
C 73.83%, H 7.89%, Cl 9.91%, N 3.91%, O 4.47%.

Description and references

Nonsedating-type histamine H1-receptor antagonist; structurally similar to clemastine, q.v. Prepn: I. Beck et al., DE 2528194 (1976 to EGYT), C.A. 85, 46439h (1976). In vitro antihistaminic activity: A. Németh, Z. Huszti, Agents Actions 23, 194 (1988). Clinical pharmacology: Z. Vezekényi et al., Acta Med. Hung. 44, 55 (1987).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 59767-13-4
EGIS-2062; EGYT-2062; Loderix (Egis).
C22H28ClNO.HCl; mol wt 394.38.
C 67.00%, H 7.41%, Cl 17.98%, N 3.55%, O 4.06%.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Aminoalkylethers