Nomenclature
CAS number: 9015-51-4
Argentoproteinum; protargin; silver proteinate; silver nucleate; silver nucleinate.
Description and references
Group of compounds characterized as colloidal
combinations of silver and protein. Variably prepd from silver oxide,
silver nitrate or other silver salts with gelatin, serum albumin,
casein or peptone. Examples of prepns: DE 105866 (1897 to Bayer); GB 18478 (1897); H. P. Kaufmann, Arzneimittel-Synthese (Springer, 1953) p
588. Generally classified as mild or strong based on their germicidal
and irritant properties. Differentiated by the amount of ionizable
silver present: Van Deripe, Konnerth, Am.
J. Pharm. 111, 65 (1939). Use to stain nerve
fibers: D. Bodian, Anat. Rec. 65, 89 (1936). Neuronal selectivity and use in light
and electron microscopy: I. S. Zagon, J. H. Haring, Acta Anat. 114, 193 (1982); in
Alzheimer's disease: C. Duyckaerts et al., Acta Neuropathol. 73, 167 (1987).
Derivative
Mild silver protein.
Nomenclature
Argentum vitellinum; Argyrol (J & J); Silvol (Parke-Davis). Properties
Brown, dark-brown, or almost black, odorless,
lustrous scales or granules. Contains ≈20% silver. Somewhat hygroscopic.
Freely sol in water. Almost insol in alcohol, chloroform, ether.
Keep well closed and protected from light.Derivative
Strong silver protein.
Nomenclature
Albumose silver; Protargol (Winthrop). Properties
Pale yellowish-orange to brownish-black, odorless
powder. Contains ≈8% silver, most of which is present in ionic form.
Somewhat hygroscopic. Freely sol in water. Almost insol in alcohol,
ether, chloroform. Keep well closed and protected
from light.Use
Neuronal-selective histological stain; general contrast
medium for electron microscopy.
Therapeutic Category
Antiseptic.
Therapeutic Category (Veterinary)
Antiseptic.
Keywords
Antiseptic/Disinfectant; Silver compounds