8535. Simetride

Nomenclature

CAS number: 154-82-5
1,4-Bis[(2-methoxy-4-propylphenoxy)acetyl]piperazine; AP2; Kyorin AP2.
C28H38N2O6; mol wt 498.61.
C 67.45%, H 7.68%, N 5.62%, O 19.25%.

Description and references

Prepn: FR M2936 (1964 to Kyorin Pharmaceutical Co., Ltd.); T. Irikura et al., US 3184463 (1965). Pharmacological studies: T. Irikura et al., Yakugaku Zasshi 83, 785 (1963), C.A. 60, 1008b (1964). Analgesic activity: K. Nishino et al., Yakugaku Zasshi 85, 715 (1965), C.A. 63, 16957b (1965).

Chemical structure

Properties

Crystals, mp 128-130° (FR M2936); also reported as mp 138.5-139° (Irikura, 1963). Practically insoluble in water, ethanol. Sol in CHCl3. LD50 i.p. in mice: 15000 mg/kg (Irikura).

Therapeutic Category

Analgesic.