8537. Simfibrate

Nomenclature

CAS number: 14929-11-4
2-(4-Chlorophenoxy)-2-methylpropanoic acid 1,3-propanediyl ester; 2-(p-chlorophenoxy)-2-methylpropionic acid trimethylene ester; 1,3-propanediol bis[α-(p-chlorophenoxy)isobutyrate]; 1,3-propanediol bis[2-(4-chlorophenoxy)-2-methylpropionate]; sinfibrate; CLY-503; Cholesolvin (Cyanamid); Liposolvin (Tosi).
C23H26Cl2O6; mol wt 469.35.
C 58.86%, H 5.58%, Cl 15.11%, O 20.45%.

Description and references

Prepn: NL 6600044 corresp to Nakanishi et al., US 3494957 (1966, 1970 to Yoshitomi). Activity and toxicology studies: Nakanishi et al., J. Pharm. Soc. Jpn. 90, 267, 921, 926 (1970). Activity on postheparin lipoprotein lipase: L. Cavallini et al., Clin. Ter. 92, 25 (1980).

Chemical structure

Properties

Crystals, mp 51-53°. bp0.03 197-200°, bp0.15 220-230°. LD50 in mice, rats (g/kg): 3.3-3.5; 7.3-8.0 orally (Nakanishi, J. Pharm. Soc. Japan).

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Fibrates