8717. Songorine
Nomenclature
CAS number: 509-24-0
(1α,15β)-21-Ethyl-1,15-dihydroxy-4-methyl-16-methylene-7,20-cycloveatchan-12-one; napellonine; zongorine. C22H31NO3; mol wt 357.49.
C 73.91%, H 8.74%, N 3.92%, O 13.43%.
Description and references
From Aconitum songoricum Popov, Ranunculaceae: Yunusov, J. Gen. Chem. USSR 18, 515 (1948); Kuzovkov, ibid. 23, 504 (1953); 25, 2006 (1955). Identity with napellonine: Kuzovkov, Zh. Obshch. Khim. 28, 2283 (1958); 29, 1728 (1959). Structure: Sugasawa, Chem. Pharm. Bull. 9, 889, 897 (1961). Absolute configuration: Okamoto et al., ibid. 13, 1270 (1965). Synthesis of the aromatic intermediate: Wiesner et al., Can. J. Chem. 51, 3978 (1973). Pharmacology: Sadritdinov, Farmakol. Alk. No. 312 (1965), C.A. 66, 93772d (1967). Mass spectra data: Yunusov et al., Khim. Prir. Soedin. 6, 101 (1970), C.A. 73, 131178u (1970). Pharmacology and toxicity data: N. G. Bisset, J. Ethnopharmacol. 4, 247-336 (1981).
