8729. Soterenol

Nomenclature

CAS number: 13642-52-9
N-[2-Hydroxy-5-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide; 2′-hydroxy-5′-[1-hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide; MJ-1992.
C12H20N2O4S; mol wt 288.36.
C 49.98%, H 6.99%, N 9.71%, O 22.19%, S 11.12%.

Description and references

β-Adrenergic agonist. Prepn: Larsen et al., J. Med. Chem. 10, 462 (1967). Pharmacological study: K. W. Dungan et al., J. Pharmacol. Exp. Ther. 164, 290 (1968).

Chemical structure

Derivative

Monohydrochloride.

Nomenclature

CAS number: 14816-67-2
C12H20N2O4S.HCl; mol wt 324.82.
C 44.37%, H 6.52%, N 8.62%, O 19.70%, S 9.87%, Cl 10.91%.

Properties

Crystals from methanol-isopropyl ether, mp 195.5-196.5° (dec). LD50 (7 day) in mice (mg/kg): 41 i.v.; 315 i.p.; 660 orally (Dungan).

Therapeutic Category

Bronchodilator.

Keywords

β-Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives