Description and references

Family of six antifungal agents, sphingofungins A-F, isolated from Aspergillus fumigatus of which sphingofungin C is the most abundant. Specific inhibitors of serine palmitoyltransferase. Isoln and charaterization of sphingofungins A-D: F. VanMiddlesworth et al., J. Antibiot. 45, 861 (1992); of sphingofungins E-F: W. S. Horn et al., ibid. 1692. Stereochemistry of A-D: F. VanMiddlesworth et al., Tetrahedron Lett. 33, 297 (1992). Mechanism of action: M. M. Zweerink et al., J. Biol. Chem. 267, 25032 (1992). Synthesis of D: K. Mori, K. Otaka, Tetrahedron Lett. 35, 9207 (1994); and stereochemistry of E: B. Wang et al., Synlett 2001, S1 904.

Derivative