8758. Spirogermanium

Nomenclature

CAS number: 41992-23-8
8,8-Diethyl-N,N-dimethyl-2-aza-8-germaspiro[4.5]decane-2-propanamine; 2-[3-(dimethylamino)propyl]-8,8-diethyl-2-aza-8-germaspiro[4.5]decane.
C17H36GeN2; mol wt 341.12.
C 59.86%, H 10.64%, Ge 21.29%, N 8.21%.

Description and references

Cytostatic germanium deriv. Prepn: L. M. Rice, DE 2243550; idem, US 3825546 (1973, 1974 both to Geschickter Fund for Med. Res.); L. M. Rice et al., J. Heterocycl. Chem. 11, 1041 (1974). Toxicology study: M. C. Henry et al., Preclinical Toxicologic Evaluation (PB-264117, 1977) 213 pp. Metabolism study: D. Garteiz et al., Drug Metab. Dispos. 19, 44 (1991). Clinical evaluation: P. S. Schein et al., Cancer Treat. Rep. 64, 1051 (1980); C. Tropie et al., ibid. 65, 119 (1981). Toxicity study: M. C. Henry et al., ibid. 64, 1207 (1980).

Chemical structure

Properties

Oil, bp0.03 106-109°.

Derivative

Dihydrochloride.

Nomenclature

CAS number: 41992-22-7
NSC-192965; Spiro-32 (Unimed).
C17H36GeN2.2HCl; mol wt 414.04.
C 49.31%, H 9.25%, Ge 17.54%, N 6.77%, Cl 17.13%.

Properties

Crystals, mp 287-288°. LD50 in rats (mg/kg): 75 i.p.; in mice (mg/kg): 150 i.p., 324 orally (Rice et al.). LD50 in male, female mice (mg/kg): 44.5, 41.5 i.v.; 142.9, 119 i.m. (Henry, 1980).

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic