8865. Succimer

Nomenclature

CAS number: 304-55-2
(2R,3S)-rel-2,3-Dimercaptobutanedioic acid; meso-2,3-dimercaptosuccinic acid; DMS; DMSA; Ro-1-7977; Chemet (McNeil).
C4H6O4S2; mol wt 182.22.
C 26.37%, H 3.32%, O 35.12%, S 35.19%.

Description and references

A water soluble chelating agent. Prepn: L. N. Owen, M. U. S. Sultanbawa, J. Chem. Soc. 1949, 3109. Pharmacology, toxicity and activity in heavy metal poisoning in animals: E. Friedheim, C. Corvi, J. Pharm. Pharmacol. 27, 624 (1975); J. H. Graziano et al., J. Pharmacol. Exp. Ther. 207, 1051 (1978). GC determn in urine: J. J. Knudsen, E. L. McGown, J. Chromatogr. 424, 231 (1988). Clinical evaluations in heavy metal poisoning: E. Friedheim et al., Lancet 2, 1234 (1978); L. Fournier et al., Med. Toxicol. 3, 499 (1988). Diagnostic use of complex with technetium in urinary tract imaging: I. G. Verber et al., Arch. Dis. Child. 63, 1320 (1988); in tumor imaging: H. Ohta et al., Nucl. Med. Commun. 9, 105 (1988). Review: H. V. Aposhian, “Biological Chelation: 2,3-Dimercaptopropanesulfonic Acid and Meso-Dimercaptosuccinic Acid” in Adv. Enzyme Regul. 20, G. Weber, Ed. (Pergamon Press, Oxford, 1982) pp 301-319. Review of pharmacology and clinical use in heavy metal poisoning: idem, Annu. Rev. Pharmacol. Toxicol. 23, 193-215 (1983); J. H. Graziano, Med. Toxicol. 1, 155-162 (1986).

Chemical structure

Properties

White crystals from aqueous methanol, mp 192-194°. LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi).

Use

Chelating agent.

Therapeutic Category

Antidote (heavy metal poisoning). 99mTc complex as diagnostic aid (radioactive imaging agent).

Keywords

Antidote (Heavy Metal Poisoning); Chelating Agent

Succimer Complex with 99mTc: Diagnostic Aid (Radioactive Imaging Agent)