8874. Succinylcholine Bromide

Nomenclature

CAS number: 55-94-7
2,2′-[(1,4-Dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium] dibromide; bis[2-dimethylaminoethyl]succinate bis[methobromide]; 3,8-dioxadecane-4,7-dione-1,10-bis[trimethylammonium bromide]; suxamethonium bromide; IS-370; compd 48/268; LT-1; M & B 2207; Brevidil M (M & B).
C14H30Br2N2O4; mol wt 450.21.
C 37.35%, H 6.72%, Br 35.50%, N 6.22%, O 14.22%.

Description and references

Prepd by reacting β-bromoethyl succinate with trimethylamine: Glick, J. Biol. Chem. 137, 357 (1941); Fusco et al., Gazz. Chim. Ital. 79, 129, 837 (1949); Walker, J. Chem. Soc. 1950, 193. Alternate prepns: Phillips, J. Am. Chem. Soc. 71, 3264 (1949); Tammelin, Acta Chem. Scand. 7, 185 (1953).

Chemical structure

Properties

Slightly hygroscopic crystals, mp 225°. Freely sol in water or normal saline, giving solns which are very slightly acidic. Aq solns undergo progressive hydrolysis with corresponding loss of activity and increase in acidity. Prepare solns just before using. The rate of this decompn increases with temp and autoclaving or prolonged exposure to warmth should be avoided.

Therapeutic Category

Neuromuscular blocking agent.

Keywords

Neuromuscular Blocking Agent; Depolarizing Agents