8893. Sulconazole

Nomenclature

CAS number: 61318-90-9
1-[2-[[(4-Chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole; (±)-1-[2,4-dichloro-β-[(p-chlorobenzyl)thio]phenethyl]imidazole.
C18H15Cl3N2S; mol wt 397.75.
C 54.35%, H 3.80%, Cl 26.74%, N 7.04%, S 8.06%.

Description and references

Prepn: K. A. M. Walker, DE 2541833; idem, US 4055652 (1976, 1977 both to Syntex). HPLC determn in plasma: M. Fass et al., J. Pharm. Sci. 70, 1338 (1981). Mechanism of action study: W. H. Beggs, Biochem. Arch. 10, 117 (1994). Clinical trial in tinea pedis: W. A. Akers et al., J. Am. Acad. Dermatol. 21, 686 (1989). Review of pharmacology and clinical efficacy: P. Benfield, S. P. Clissold, Drugs 35, 143-153 (1988).

Chemical structure

Derivative

Nitrate.

Nomenclature

CAS number: 61318-91-0
RS-44872; Exelderm (Syntex); Myk (Cassenne); Sulcosyn (Syntex).
C18H15Cl3N2S.HNO3; mol wt 460.76.
C 46.92%, H 3.50%, Cl 23.08%, N 9.12%, S 6.96%, O 10.42%.

Properties

Colorless crystals from acetone, mp 130.5-132°.

Therapeutic Category

Antifungal.

Keywords

Antifungal (Synthetic); Imidazoles