Description and references

Murine antigranulocyte monoclonal Fab′ antibody fragment directed against nonspecific crossreactive antigen-90 (NCA-90), a surface glycoprotein on granulocytes, and cross reactive with carcinoembryonic antigen (CEA). ^99mTechnetium radiolabeled immunoconjugate designed for imaging activated granulocytes. Prepn and characterization as an anti-CEA antibody: H. J. Hansen et al., Cancer 71, 3478 (1993). Prepn of radiolabeled form: idem et al., US 5328679 (1994 to Immunomedics). Pharmacology and immunoscintigraphy: W. Becker et al., Semin. Nucl. Med. 24, 142 (1994). Clinical study in detection of osteomyelitis: S. J. Harwood et al., Clin. Infect. Dis. 28, 1200 (1999); of appendicitis: B. Baron et al., Surgery 125, 288 (1999).

Derivative