8928. p-Sulfanilylbenzylamine

Nomenclature

CAS number: 4393-19-5
4-[(4-Aminophenyl)sulfonyl]benzenemethanamine; p-sulfanilidobenzylamine; 4-aminomethyl-4′-aminodiphenyl sulfone; p-aminophenyl-p-aminomethylphenyl sulfone; Alphamide.
C13H14N2O2S; mol wt 262.33.
C 59.52%, H 5.38%, N 10.68%, O 12.20%, S 12.22%.

Description and references

Prepn: Dewing, J. Chem. Soc. 1946, 466; Wenner, J. Org. Chem. 22, 1508 (1957).

Chemical structure

Properties

Needles from water, mp 159°.

Derivative

Monohydrochloride monohydrate.
C13H14N2O2S.HCl.H2O; mol wt 316.80.
C 49.29%, H 5.41%, N 8.84%, O 15.15%, S 10.12%, Cl 11.19%.

Properties

Crystals, mp 195°. Very sol in water.

Derivative

Dihydrochloride.
C13H14N2O2S.2HCl; mol wt 335.25.
C 46.57%, H 4.81%, N 8.36%, O 9.54%, S 9.56%, Cl 21.15%.

Properties

mp 285°.

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Synthetic); Sulfones