8944. Sulfathiourea

Nomenclature

CAS number: 515-49-1
4-Amino-N-(aminothioxomethyl)benzenesulfonamide; 1-sulfanilyl-2-thiourea; sulfathiocarbamide; RP-2255; Badional; Fontamide.
C7H9N3O2S2; mol wt 231.30.
C 36.35%, H 3.92%, N 18.17%, O 13.83%, S 27.73%.

Description and references

Prepd by reacting acetylsulfanilylcyanamide with hydrogen sulfide. Has also been prepd directly from sulfanilyl cyanamide and ammonium sulfide: Leitch et al., Can. J. Res. 23B, 139 (1945); alternate method: Fldi et al., US 2332906 (1943).

Chemical structure

Properties

Crystals, dec 171.5-172°. Soly in water at 37°: 1.1 g/100 ml.

Derivative

Sodium salt.

Nomenclature

CAS number: 6101-34-4
C7H8N3NaO2S; mol wt 221.21.
C 38.01%, H 3.65%, N 19.00%, Na 10.39%, O 14.47%, S 14.50%.

Properties

Dec 245-245.5°. Very sol in water. pH of 1% aq soln: 7.

Derivative

Water sol form.

Nomenclature

Solufontamide.

Properties

Marketed as a slightly viscous soln contg 33% of 1-sulfanilyl-2-thiourea. d415 1.16. pH 6.8-7.2.

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Synthetic); Sulfonamides