8948. Sulfinalol

Nomenclature

CAS number: 66264-77-5
4-Hydroxy-α-[[[3-(4-methoxyphenyl)-1-methylpropyl]amino]methyl]-3-(methylsulfinyl)benzenemethanol; 4-hydroxy-α-[[[3-(p-methoxyphenyl)-1-methylpropyl]amino]methyl]-3-(methylsulfinyl)benzyl alcohol.
C20H27NO4S; mol wt 377.50.
C 63.63%, H 7.21%, N 3.71%, O 16.95%, S 8.49%.

Description and references

β-Adrenergic blocker. Prepn: R. E. Philion, DE 2728641 (1978 to Sterling), C.A. 90, 137468 (1979). Pharmacological activity profile: P. H. Hernández, Fed. Proc. 38, 738 (1979). Chromatographic determn in human plasma and urine: G. B. Park et al., Anal. Chem. 53, 604 (1981). Metabolism, disposition in animals: D. P. Benziger et al., Drug Metab. Dispos. 9, 493 (1981).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 63251-39-8
Win-40808-7; Perifadil (Sterling Winthrop).
C20H27NO4S.HCl; mol wt 413.96.
C 58.03%, H 6.82%, N 3.38%, O 15.46%, S 7.75%, Cl 8.56%.

Properties

Crystals, mp 172-175°.

Therapeutic Category

Antihypertensive.

Keywords

β-Adrenergic Blocker; Antihypertensive; Arylethanolamine Derivatives