8954. Sulfobromophthalein Sodium

Nomenclature

CAS number: 71-67-0
3,3′-(4,5,6,7-Tetrabromo-3-oxo-1(3H)-isobenzofuranylidene)bis[6-hydroxybenzenesulfonic acid] disodium salt; disodium phenoltetrabromophthalein sulfonate; bromosulfophthalein; BSP; Bromsulphalein (Becton Dickinson); Bromthalein (Merck KGaA).
C20H8Br4Na2O10S2; mol wt 838.00.
C 28.67%, H 0.96%, Br 38.14%, Na 5.49%, O 19.09%, S 7.65%.

Description and references

Prepd by the condensation of phenol and tetrabromophthalic acid or its anhydride, followed by sulfonation and conversion to the disodium salt. Pharmacology and use as liver function test: S. M. Rosenthal, E. C. White, J. Pharmacol. 24, 265 (1924); W. Hcki et al., J. Lab. Clin. Med. 88, 1019 (1976).

Chemical structure

Properties

Hygroscopic crystals. Bitter taste. Sol in water. Insol in alcohol, acetone. Alkaline solns have an intense bluish-purple color.

Therapeutic Category

Diagnostic aid (hepatic function).

Therapeutic Category (Veterinary)

Diagnostic aid (hepatic function).

Keywords

Diagnostic Aid