8968. Sulfoxone Sodium

Nomenclature

CAS number: 144-75-2
Disodium[sulfonylbis(p-phenylenimino)]dimethanesulfinate; 4,4′-diaminodiphenylsulfone disodium formaldehyde sulfoxylate; disodium formaldehydesulfoxylate-diaminodiphenylsulfone; aldesulfone sodium; Diazon; Novotrone; Diasone (Abbott).
C14H14N2Na2O6S3; mol wt 448.45.
C 37.50%, H 3.15%, N 6.25%, Na 10.25%, O 21.41%, S 21.45%.

Description and references

Prepn: H. Bauer, J. Am. Chem. Soc. 61, 617 (1939); S. M. Rosenthal, H. Bauer, US 2234981 (1941); G. W. Raiziss et al., J. Am. Pharm. Assoc. 33, 43 (1944); US 2256575 (1941). Therapeutic use in dermatitis herpetiformis: T. Cornbleet, Arch. Dermatol. Syphilol. 64, 684 (1951); S. I. Katz, Arch. Dermatol. 118, 809 (1982); in leprosy: J. H. Peters et al., Lepr. Rev. 46, 171 (1975). Comprehensive description: V. K. Kapoor, Anal. Profiles Drug Subs. 19, 553-573 (1990).

Chemical structure

Derivative

Dihydrate.

Properties

Needles or amorphous powder. After drying at 100-110° it dec 263-265°. Easily sol in water. Slightly sol in alcohol. Practically insol in the usual organic solvents. Must be stored in vacuum-sealed ampuls. The addition of 10% sodium bicarbonate helps to prevent oxidative changes.

Therapeutic Category

Antibacterial (leprostatic).

Keywords

Antibacterial (Synthetic); Sulfones; Antibacterial (Leprostatic)