9017. Syrosingopine

Nomenclature

CAS number: 84-36-6
18-[[4-[(Ethoxycarbonyl)oxy]-3,5-dimethoxybenzoyl]oxy]-11,17-dimethoxyyohimban-16-carboxylic acid methyl ester; methyl carbethoxysyringoyl reserpate; carbethoxysyringoyl methyl reserpate; methyl O-(O′-carbethoxysyringoyl)reserpate; syringopine; Su-3118; Isotense (Nicholas); Londomin (Taiyo); Raunova (Zambeletti); Seniramin (Hokuriku); Siringina (Toyo Jozo).
C35H42N2O11; mol wt 666.71.
C 63.05%, H 6.35%, N 4.20%, O 26.40%.

Description and references

Prepn: Lucas et al., J. Am. Chem. Soc. 81, 1928 (1959); US 2813871 (1957 to Ciba).

Chemical structure

Properties

Crystals from acetone, mp 175-179°.

Therapeutic Category

Antihypertensive.

Keywords

Antihypertensive; Reserpine Derivatives