Description and references

Centrally active anticholinesterase; cognition enhancer. Prepn: Braun et al., Ber. 64, 227 (1931); Albert, Gledhill, J. Soc. Chem. Ind. 64, 169T (1945); Petrow, J. Chem. Soc. 1947, 634; J. A. Moore, L. D. Kornreich, Tetrahedron Lett. 4, 1277 (1963). Pharmacology and toxicity: S. Gershon, F. H. Shaw, J. Pharm. Pharmacol. 10, 638 (1958). Enzyme inhibiting activity: P. N. Kaul, ibid. 14, 243 (1962). Neuropharmacology: B. Drukarch et al., Life Sci. 42, 1011 (1988). Spectrofluorimetric determn in serum: I. Aparico et al., Analyst 123, 1575 (1998). Clinical trial in severe Alzheimer's disease: W. K. Summers et al., N. Engl. J. Med. 315, 1241 (1986). See also: ibid. 316, 1603-1606. Clinical evaluation of reduced mortality in dementia: B. R. Ott, K. L. Lapane, J. Am. Geriatr. Soc. 50, 35 (2002). Review of pharmacology and clinical uses: W. K. Summers et al., Clin. Toxicol. 16, 269-281 (1980); of cholinesterase inhibition in Alzheimer's disease: N. Qizilbash et al., J. Am. Med. Assoc. 280, 1777-1782 (1998).

Properties

Derivative