9039. Talipexole

Nomenclature

CAS number: 101626-70-4
5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amine; 6-allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine.
C10H15N3S; mol wt 209.31.
C 57.38%, H 7.22%, N 20.08%, S 15.32%.

Description and references

α2-Adrenoceptor and dopamine D2-receptor agonist. Prepn: G. Griss et al., DE 2040510 (1972 to Thomae); eidem, US 3804849 (1974 to Boehringer, Ing.). Dopaminergic effects: P. A. Johansen et al., Life Sci. 43, 515 (1988); S. K. Kulkarni, K. Chopra, Methods Find. Exp. Clin. Pharmacol. 12, 99 (1990). Clinical evaluation in Parkinson's disease: Y. Mizuno et al., Drug Invest. 5, 186 (1993).

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 36085-73-1
B-HT-920; Domin (Boehringer, Ing.).
C10H15N3S.2HCl; mol wt 282.23.
C 42.56%, H 6.07%, N 14.89%, S 11.36%, Cl 25.12%.

Properties

mp 245° (dec).

Therapeutic Category

Antiparkinsonian.

Keywords

α-Adrenergic Agonist; Antiparkinsonian; Dopamine Receptor Agonist