9096. Tecadenoson

Nomenclature

CAS number: 204512-90-3
N-[(3R)-Tetrahydro-3-furanyl]adenosine; CVT-510.
C14H19N5O5; mol wt 337.33.
C 49.85%, H 5.68%, N 20.76%, O 23.71%.

Description and references

Selective adenosine A1-receptor agonist. Prepn: R. T. Lum et al., WO 9808855; eidem, US 5789416 (both 1998 to CV Therapeutics). Clinical effect on AV nodal conduction: B. B. Lerman et al., J. Cardiovasc. Pharmacol. Ther. 6, 237 (2001). Clinical evaluation in paroxysmal supraventricular tachycardia: E. N. Prystowsky et al., J. Am. Coll. Cardiol. 42, 1098 (2003); K. A. Ellenbogen et al., Circulation 111, 3202 (2005). Review of pharmacology and clinical experience: A. Zaza, Curr. Opin. Investig. Drugs 3, 96-100 (2002); J. W. Cheung, B. B. Lerman, Cardiovasc. Drug Rev. 21, 277-292 (2003).

Chemical structure

Therapeutic Category

Antiarrhythmic.

Keywords

Antiarrhythmic; Adenosine Receptor Agonist