9099. Technetium 99mTc Bicisate

Nomenclature

CAS number: 121281-41-2
(SP-5-35)-[[Diethyl-N,N′-1,2-ethanediylbis[l-cysteinato]](3)-N,N′,S,S′]oxotechnetium-99mTc; [N,N′-ethylenedi-l-cysteinato(3)]oxo[99mTc]technetium(V) diethyl ester; technetium 99mTc ethyl cysteinate dimer; 99mTc-l,l-ECD; RP-217; Neurolite (BMS).
C12H21N2O5S299mTc.

Description and references

Neutral, lipophilic complex which rapidly crosses bloodbrain barrier. Prepn: P. L. Bergstein et al., EP 279417 (1988 to DuPont); eidem, US 5279811 (1994 to DuPont Merck). Pharmacology: R. C. Walovitch et al., J. Nucl. Med. 30, 1892 (1989). Clinical pharmacokinetics: S. Vallabhajosula et al., ibid. 599. Metabolism in humans: R. C. Walovitch et al., Neuropharmacology 30, 283 (1991). TLC determn of radiochemical purity: J. M. Green et al., J. Nucl. Med. Technol. 22, 21 (1994). Series of articles on clinical pharmacology and diagnostic use in SPECT brain imaging: J. Cereb. Blood Flow Metab. 14, Suppl. 1, S1-S120 (1994).

Chemical structure

Therapeutic Category

Diagnostic aid (radioactive imaging agent).

Keywords

Diagnostic Aid (Radioactive Imaging Agent)