9132. Temafloxacin

Nomenclature

CAS number: 108319-06-8
1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid; T-1258; A-63004; Teflox (Abbott); Temac (Abbott); Omniflox (Abbott).
C21H18F3N3O3; mol wt 417.38.
C 60.43%, H 4.35%, F 13.66%, N 10.07%, O 11.50%.

Description and references

Trifluorinated quinolone antibacterial. Prepn: D. T. W. Chu, EP 131839; idem, US 4730000 (1985, 1988 to Abbott). Antibacterial activities: D. J. Hardy et al., Antimicrob. Agents Chemother. 31, 1768 (1987); K. V. I. Rolston et al., Eur. J. Clin. Microbiol. Infect. Dis. 7, 684 (1988); in comparison with other fluoroquinolones: A. L. Barry, R. N. Jones, J. Antimicrob. Chemother. 23, 527 (1989).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 105784-61-0
A-62254.
C21H18F3N3O3.HCl; mol wt 453.84.
C 55.58%, H 4.22%, F 12.56%, N 9.26%, O 10.58%, Cl 7.81%.