9160. Terconazole

Nomenclature

CAS number: 67915-31-5
rel-1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine; triaconazole; R-42470; Fungistat (Cilag); Gyno-Terazol (Cilag); Terazol (Cilag); Tercospor (Cilag).
C26H31Cl2N5O3; mol wt 532.46.
C 58.65%, H 5.87%, Cl 13.32%, N 13.15%, O 9.01%.

Description and references

Topical triazole antifungal. Prepn: J. Heeres et al., DE 2804096; eidem, US 4144346; US 4223036 (1978, 1979, 1980 all to Janssen); eidem, J. Med. Chem. 26, 611 (1983). Pharmacology: J. Van Cutsem et al., Chemotherapy 29, 322 (1983). Clinical comparison with clotrimazole in vaginal candidiasis: A. Kjaeldgaard, Pharmatherapeutica 4, 525 (1986).

Chemical structure

Properties

Crystals from isopropyl ether, mp 126.3°.

Therapeutic Category

Antifungal.

Keywords

Antifungal (Synthetic); Triazoles