9302. Thiamylal

Nomenclature

CAS number: 77-27-0
Dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione; 5-allyl-5-(1-methylbutyl)-2-thiobarbituric acid; thioseconal.
C12H18N2O2S; mol wt 254.35.
C 56.67%, H 7.13%, N 11.01%, O 12.58%, S 12.61%.

Description and references

Prepn: GB 613704 (1948 to Lilly); Abe et al., J. Pharm. Soc. Jpn. 75, 891 (1955); Izumi, Nakanishi, JP 56 8785 (1956 to Yoshitomi); Donnison, US 2876225 (1959 to Abbott).

Chemical structure

Properties

Crystals from dil ethanol, mp 132-133°.

Derivative

Sodium salt.

Nomenclature

CAS number: 337-47-3
Surital (Warner-Lambert).
C12H17N2NaO2S; mol wt 276.33.
C 52.16%, H 6.20%, N 10.14%, Na 8.32%, O 11.58%, S 11.60%.

Note

This is a controlled substance (depressant): 21 CFR, 1308.13.

Therapeutic Category

Anesthetic (intravenous).

Therapeutic Category (Veterinary)

Anesthetic (intravenous).

Keywords

Anesthetic (Intravenous)