9315. Thiethylperazine

Nomenclature

CAS number: 1420-55-9
2-(Ethylthio)-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine; 3-ethylmercapto-10-(1′-methylpiperazinyl-4′-propyl)phenothiazine.
C22H29N3S2; mol wt 399.62.
C 66.12%, H 7.31%, N 10.52%, S 16.05%.

Description and references

Prepn: Bourquin et al., Helv. Chim. Acta 41, 1072 (1958).

Chemical structure

Properties

Crystals from acetone, mp 62-64°. bp0.01 227°.

Derivative

Dimaleate.

Nomenclature

CAS number: 1179-69-7
GS-95; NSC-130044; Torecan (Novartis); Toresten (Sankyo).
C22H29N3S2.2C4H4O4; mol wt 631.76.
C 57.03%, H 5.90%, N 6.65%, S 10.15%, O 20.26%.

Properties

Crystals from methanol, dec 188-190°.

Derivative

Dihydrochloride.
C22H29N3S2.2HCl; mol wt 472.54.
C 55.92%, H 6.61%, N 8.89%, S 13.57%, Cl 15.01%.

Properties

Crystals from ethanol, mp 214-216°.

Derivative

Dimalate.

Nomenclature

CAS number: 52239-63-1
C22H29N3S2.2C4H6O5; mol wt 667.79.
C 53.96%, H 6.19%, N 6.29%, S 9.60%, O 23.96%.

Properties

Crystals from ethanol, mp 139°.

Therapeutic Category

Antiemetic.

Keywords

Antiemetic