9357. Thioproperazine

Nomenclature

CAS number: 316-81-4
N,N-Dimethyl-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazine-2-sulfonamide; 3-dimethylsulfamoyl-10-[3-(4-methylpiperazino)propyl]phenothiazine; 2-dimethylsulfamoyl-10-[3′-(4″-piperazino)propyl]phenothiazine; thioperazine; RP-7843; SKF-5883.
C22H30N4O2S2; mol wt 446.63.
C 59.16%, H 6.77%, N 12.54%, O 7.16%, S 14.36%.

Description and references

Prepn: GB 814512 (1959 to Rhne-Poulenc).

Chemical structure

Properties

Crystals, mp 140°.

Derivative

Fumarate.
C22H30N4O2S2.C4H4O4; mol wt 562.70.
C 55.50%, H 6.09%, N 9.96%, O 17.06%, S 11.40%.

Properties

Crystals, mp 182°.

Derivative

Dimethanesulfonate.

Nomenclature

CAS number: 2347-80-0
Thioproperazine mesylate; Majeptil (RPR); Vontil (SKB).
C22H30N4O2S2.2CH3SO3H; mol wt 638.84.
C 45.12%, H 6.00%, N 8.77%, O 20.04%, S 20.08%.

Therapeutic Category

Antipsychotic; antiemetic.

Keywords

Antiemetic; Antipsychotic; Phenothiazines