9362. Thiosinamine

Nomenclature

CAS number: 109-57-9
N-2-Propen-1-ylthiourea; allyl thiourea; allylthiocarbamide; Aminosin (DDR); Rhodalline.
C4H8N2S; mol wt 116.18.
C 41.35%, H 6.94%, N 24.11%, S 27.60%.

Description and references

Made by warming a mixture of equal parts of allyl mustard oil and abs alcohol with an equal amount of 30% ammonia. Growth regulating activity: Karanov, Vasilev, Izv. Inst. Fiziol. Rast. Bulg. Akad. Nauk 16, 167 (1970), C.A. 73, 119454y (1970). Mechanism of action studies as an egg suppressive agent in schistosomiasis, A. B. Machado et al., J. Parasitol. 56, 392 (1970). In vivo and in vitro effects: I. Popiel, D. A. Erasmus, Trans. R. Soc. Trop. Med. Hyg. 75, 287 (1981). Toxicity study: S. H. Dieke et al., J. Pharmacol. Exp. Ther. 90, 260 (1947).

Chemical structure

Properties

White crystals; bitter taste; slight garlic odor; d 1.22; mp 78°. Sol in about 30 parts water; sol in alcohol, slightly sol in ether. Insol in benzene. LD50 orally in rats: 200 mg/kg (Dieke).

Therapeutic Category (Veterinary)

Has been used to minimize scar tissue.