9426. Tibezonium Iodide

Nomenclature

CAS number: 54663-47-7
N,N-Diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethanaminium iodide; diethylmethyl[2-[[4-[p-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethyl]ammonium iodide; 2-[β-(N-diethylamino)ethylthio]-4-(p-phenylthio)phenyl-3H-1,5-benzodiazepine methiodide; thiabenzazonium iodide; Rec-15-0691; Antoral (Recordati).
C28H32IN3S2; mol wt 601.61.
C 55.90%, H 5.36%, I 21.09%, N 6.98%, S 10.66%.

Description and references

1,5-Benzodiazepine deriv with bactericidal activity. Prepn: D. Nardi et al., CH 555347 (1974 to Recordati), C.A. 82, 43480 (1975). Synthesis, physical characteristics, antibacterial activity: eidem, Experientia 31, 440 (1975); eidem, Farmaco Ed. Sci. 30, 248 (1975). Structure activity study: C. Greico et al., ibid. 32, 909 (1977). Antimicrobial activity: M. Veronese et al., Chemotherapy 23, 90 (1977). Toxicity study: D. Nardi et al., Experientia 31, 440 (1975).

Chemical structure

Properties

Crystals from isopropanol, mp 162°. LD50 in mice, rats (mg/kg): 9000, >10000 orally; 42, 35 i.p. (Nardi).

Therapeutic Category

Antibacterial.

Keywords

Antiseptic/Disinfectant; Quaternary Ammonium Compounds