9460. Tiquizium Bromide

Nomenclature

CAS number: 71731-58-3
(5R,9aR)-rel-3-(Di-2-thienylmethylene)octahydro-5-methyl-2H-quinolizinium bromide; 3-(di-2-thienylmethylene)-5-methyl-trans-quinolizidinium bromide; HSR-902; HS-902; Thiaton (Hokuriku Seiyaku).
C19H24BrNS2; mol wt 410.43.
C 55.60%, H 5.89%, Br 19.47%, N 3.41%, S 15.63%.

Description and references

Quaternary ammonium salt with anticholinergic activity. Prepn: H. Kato et al., BE 866988 (1978 to Hokuriku), C.A. 90, 151996p (1979); H. Kato, E. Koshinaka, US 4205074 (1980 to Hokuriku). Synthesis and anticholinergic activity: E. Koshinaka et al., Chem. Pharm. Bull. 27, 1454 (1979). Pharmacological comparison with other antispasmodics: S. Kubo et al., Jpn. J. Pharmacol. 30, 103P (1980). Pharmacology: M. Yamazaki et al., Oyo Yakuri 23, 417, 423 (1981), C.A. 97, 66016u, 66017v (1982). HPLC determn in biological fluids: T. Yamada et al., Yakugaku Zasshi 103, 1319 (1983), C.A. 100, 131957y (1984).

Chemical structure

Properties

Needles from methanol-acetone, mp 278-281° (dec).

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic; Antimuscarinic