9462. Tiratricol

Nomenclature

CAS number: 51-24-1
[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid; 3,3′,5-triiodo-4-(4-hydroxyphenoxy)phenylacetic acid; 3,5-diiodo-4-(3-iodo-4-hydroxyphenoxy)phenylacetic acid; 3,3′,5-triiodothyroacetic acid; Triac (Aché); Triacana (Marcofina).
C14H9I3O4; mol wt 621.93.
C 27.04%, H 1.46%, I 61.21%, O 10.29%.

Description and references

Thyroid hormone analog. Prepd by iodination of 4-(4′-hydroxyphenoxy)-3,5-diiodophenylacetic acid: Wilkinson, Biochem. J. 63, 601 (1956); Hems, GB 803149 (1958 to Glaxo); Wilkinson, GB 805761 (1958 to Nat. Res. Dev. Corp.); Meltzer et al., J. Org. Chem. 26, 1418 (1961). Clinical evaluation in thyroidectomy: S. I. Sherman, P. W. Ladenson, J. Clin. Endocrinol. Metab. 75, 901 (1992).

Chemical structure

Properties

Needles from methanol+ water, mp 65°, resolidifies 110°, mp 180-183°.

Therapeutic Category

Antihypothyroid.

Keywords

Antihypothyroid