9506. Tolazoline

Nomenclature

CAS number: 59-98-3
4,5-Dihydro-2-(phenylmethyl)-1H-imidazole; 2-benzyl-2-imidazoline; 2-benzyl-2-iminazoline; benzazoline; 2-benzyl-4,5-imidazoline; phenylmethylimidazoline.
C10H12N2; mol wt 160.22.
C 74.96%, H 7.55%, N 17.48%.

Description and references

α-Adrenergic blocker. Prepn: Sonn, US 2161938 (1939 to Ciba). HPLC determn in serum: L. M. L. Todesco et al., Ther. Drug Monit. 9, 78 (1987). Review of pharmacology and clinical use: R. M. Ward, Clin. Perinatol. 11, 703-713 (1984).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 59-97-2
Priscol (Novartis); Priscoline (Novartis); Tolazine (Lloyd); Vaso-Dilatan (Schwarz).
C10H12N2.HCl; mol wt 196.68.
C 61.07%, H 6.66%, N 14.24%, Cl 18.03%.

Properties

Bitter crystals, mp 174°. Freely sol in water, alcohol; sol in chloroform; very slightly sol in ether, ethyl acetate. pH of 2.5% soln 4.9-5.3.

Therapeutic Category

Vasodilator (peripheral).

Therapeutic Category (Veterinary)

Reversal agent for xylazine.

Keywords

α-Adrenergic Blocker; Vasodilator (Peripheral)